Balmaña J., et al, carried out a registry of the results of hereditary cancer multigene panels from different laboratories, reporting contradictory interpretations in 26% of the interpreted variants, with greater frequency among the CHEK2 and ATM genes, followed by RAD51C, PALB2, BARD1, NBN, and BRIP1 (Balmaña et al., 2016). This evidence concerns the gene CHEK2 and hereditary cancer.