XPC and xeroderma pigmentosum: Regarding the remaining 2/8 P/LP variants reclassified to a less severe category, the variant in the XPC gene [(NM_004628.5:c.1001C) > A;p.(Pro334His)] previously interpreted as P was downgraded as B; this variant was found in a heterozygous state, therefore, the patient was not diagnosed with xeroderma pigmentosum (MIM278720), and its reclassification did not modify the patient's diagnosis or management.