CHEK2 and breast carcinoma: The other variant in the CHEK2 gene [NM_001005735.2:c.1556C > T;p.(Thr519Met)] previously interpreted as LP was downgraded to VUS; since for this gene only frameshift P/LP variants are considered as risk factors, the reclassification of this missense variant did not have profound effects on the medical care of the carriers; accordingly, screening recommendations for breast cancer are based on family history (Näslund‐Koch et al., 2016; NCCN Guidelines Version 1., 2023).