While prior studies have examined the effects of exercise on BAT function, the reverse scenario (i.e., potential effects of BAT on exercise capacity) has been essentially ignored, despite the fact that transplantation of normal BAT is known to confer multiple beneficial effects, most notably anti‐obesity and anti‐diabetes actions, such as improved glucose metabolism and insulin sensitivity (White et al., 2019). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.