In contrast, IBA1 immunostaining in NS−/− mice was higher in the control and AAV-GFP treatment groups (p < 0.0001) and significantly elevated under glaucoma conditions (p < 0.0001) while being decreased (p < 0.0001) in glaucomatous animals with AAV-NS treatment (Figures S34G–S34I). The gene discussed is AIF1; the disease is glaucoma.