MMP2 and myocardial infarction: A bifunctional myocardial infarction (MI)-responsive peptide sequence, GCNS-GGRMSMPV-KLTWQELYQLKYKGI (GGR-KLT) consisting of both a therapeutic KLT and a cleavable GGR sequence was developed, and further bound to MaHA through Michael addition using both MaHA maleimide and GGR sulfhydryl groups in order to stimulate angiogenesis through matrix metalloproteinase-2 (MMP 2).