In patients with mild to moderate keratoconus, daily supplementation with a highly-concentrated DHA triglyceride (1000 mg/day) nutritional supplement for 3 months was associated with significant improvements in antioxidant (TAC, MDA, GSH/GSSG) and inflammatory status (IL-4, IL-6, TNF-α, VEGF-A) biomarkers as compared with untreated controls. This evidence concerns the gene IL4 and keratoconus.