Regardless of different treatment modalities of corneal surgery, particularly for advanced corneal ectasias [14], the involvement of inflammatory mediators (interleukins (IL) and tumor necrosis factor alpha (TNF-α)), matrix metalloproteinases (MMP-9), oxidative stress-related products, and nutritional and/or metabolic imbalance, affecting a variety of metabolites, hormones, micronutrients, vitamins, minerals, and fatty acids [3] has been the rationale of including diet changes and nutritional supplementation in traditional conservative management of keratoconus [15]. The gene discussed is TNF; the disease is keratoconus.