Iman Fatemi et al. reported that chronic supplementation of CoQ10 has a potential protective effect on the brain after stroke and can reduce the sequelae of ischemia/cerebral perfusion injury, which may be related to the increase in brain-derived neurotrophic factor (BDNF) level and superoxide dismutase (SOD) activity in brain tissue [50]. Here, BDNF is linked to ischemia.