GH1 and Prader-Willi syndrome: Therefore, the aim of this study was: (i) to analyze the differences in the profiles of circulating peptides regulating appetite—mainly nesfatin-1 and spexin—in children with PWS undergoing GH treatment and reduced energy intake with the profiles in healthy, non-obese children, and (ii) to evaluate the relationships between the biochemical parameters and anthropometric indices in children with PWS during GH treatment and dietary intervention.