SPTLC3 and fatty liver disease: N-3 PUFAs downregulate Sptlc3 and Degs2-CerS corresponding genes, reducing CerS activity (Cer16:0, Cer18:0, Cer20:0, Cer22:0, and Cer24:0) and decreasing hepatic steatosis in a hyperhomocysteinemia-induced hepatic steatosis mouse model [76].