HAPLN4 and coronary artery disorder: As for HAPLN4, it has been predicted to be involved in the central nervous system, skeletal and hyaluronic acid binding activity [20], and it has been also identified as a common variant associated with plasma levels of different lipid species and with coronary artery diseases in a GWAS performed by Cadby et al. on individuals from the Busselton Health Study and the UK Biobank [21].