On the other side, given the fact that (i) insulin was found to down-regulate taste buds’ cell expression in a dose-dependent manner [62] and that (ii) obesity is associated with the development of insulin resistance, alterations in the sense of taste have been speculated to be a consequence of metabolic disturbances related to extreme overweight [16]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.