In addition, in another RCT, patients with severe sepsis treated with GH 0.1 mg/kg/day or placebo during the second, third, and fourth day after admission showed that GH administration decreased nitrogen production (p < 0.01) and nitrogen balance became positive in the GH group during treatment on day 3 (p < 0.05) [45]. The gene discussed is GH1; the disease is Sepsis.