Diosmin, another natural-derived AHR ligand, increased FLG expression and epidermal thickness as well as was able to reverse the Th2 cytokine-mediated FLG downregulation in normal human epidermal keratinocytes, thus it has been suggested to be the most promising phytochemical for atopic dermatitis treatment [240]. This evidence concerns the gene FLG and atopic eczema.