IL1B and Parkinson disease: It has also been reported that echinacoside improved neuropathological status in mice with Parkinson’s disease via neuroprotection and inhibition of activated microglia-mediated nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3), Caspase (CASP)-1, and interleukin-1β (IL-1β) signals of inflammation [99].