STAT3 and colorectal cancer: Further, 18βGA inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, protein kinase B (AKT), signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinases (JNK), p38, and nuclear factor kappa B (NF-κB) p65 protein levels as well as cell migration, invasion, and wound healing [25] suggested that 18βGA might be potentially helpful in treating colorectal cancer patients (Table 1).