HTT and Huntington disease: The therapeutic effect against HD of esculetin (Figure 18), a coumarin derivative with possible neuroprotective effects, was tested by Pruccoli et al. In their study, the authors demonstrated that, in a PC12-inducible Drosophila melanogaster HD transgenic model expressing fragments of the mutated HTT protein (mHTT) esculetin decreased OS and mitochondrial deterioration generated by mHTT and inhibited cell death [96].