Aesculin (7-hydroxy-6-O-glucosylcoumarin) (Figure 5), another coumarin derivative, demonstrated protective effects on dextran sulfate sodium (DSS)- and TNBS-induced intestinal inflammation by counteracting glutathione (GSH) depletion and inhibiting myeloperoxidase (MPO) activity, thereby suppressing clinical indicators of intestinal inflammation and histopathological damage promoted by DSS. The gene discussed is MPO; the disease is inflammatory response.