NFKBIA and injury: It is reported that the methanol extract of Antrodia camphorata can efficiently inhibit the protein expression of COX-2 and INOS, the degradation of NF-κB and IκBα, and the phosphorylation of MAPKs; it also can suppress pro-inflammatory mediators such as NO, TNF-α, IL-1β, and IL-6 during LPS-induced lung injury [28].