NGF and Cognitive impairment: Epigallocatechin gallate (EGCG), the most abundant polyphenol component in green tea, was found to decrease cognitive impairment in β-amyloid precursor protein/presenilin 1 (APP/PS1) mice by increasing nerve growth factor (NGF) expression and by promoting Cyclic Adenosine monophosphate (cAMP)-response element binding protein (CREB) expression [8].