In a melanoma model, a combined regimen of vaccination, based on a flagellin-adjuvanted tumor-specific peptide and photodynamic therapy, showed a systemic and local response of peptide tumor antigen-specific IFNγ-secretion and accumulation of effector memory CD8+ T cells [18], and that immune response was enhanced when an immune checkpoint inhibitor was used in parallel. This evidence concerns the gene IFNG and neoplasm.