BCL2 and cancer: Chlorogenic acid potentiated the apoptotic effect of certain anti-cancer agents via activation of apoptosis-related molecules, namely Bcl-2-associated X protein (Bax) and Caspase 3/7, and inhibition of anti-apoptotic molecules, namely B-cell/CLL lymphoma-2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL), by modulating the PI3K/Akt signaling pathway [73].