By contrast, CQ alone increased cleaved PARP and cleaved caspase-3 in HepG2 cells (Figure 7B), suggesting an interesting scenario that autophagy may play a protective role in HepG2 cells, but autophagy induced by UDCMe-Z-DHA may contribute to apoptosis of HepG2 cells as in MM cells [41]. This evidence concerns the gene CASP3 and Miyoshi myopathy.