TNF and infection: During the initial stage of trauma or infection, body initiates various cellular and molecular events which include the secretion of many proinflammatory cytokines and chemokines such as interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) as well as reactive oxygen species (ROS) and nitric oxide (NO) to restore tissue homeostasis and resolve acute inflammation [2,3].