WEE1 and cancer: Similar to the aforementioned cancers, GTCs have been found to have both curative and preventive effects on lung cancer through obstruction of key protein kinases and regulation of molecular signals and gene expression of cyclin D1, Bcl-2, p21, p53, VEGF, Bax COX-2, Caspase-3, -7, and -9 [145,146,147].