Due to the higher sensitivity of ATP compared to other P2X subtypes, the ATP-P2X1 axis is actively involved in vasoconstriction in the vasculature, while in cardiomyocytes, a close association of P2X1 and ATP release channel and connexin-1 was found in patients with dilated cardiomyopathy; the pathological significance remains obscure [229]. The gene discussed is P2RX1; the disease is dilated cardiomyopathy.