CX3CL1 and psoriasis: The Picea mariana extract inhibits the IκBα degradation and migration of p50/p65 subunit to the psoriatic keratinocyte nucleus, thereby avoiding the transcription for many proteins involved in the psoriasis pathogenesis, such as IL-6, IL-8, CX3CL1/fractalkine, iNOS, elafin, VEGF, and ICAM-1.