GLA and X-linked disease: Fabry Disease (FD, OMIM 301500), the second-most prevalent lysosomal storage disorder (LSD) after Gaucher disease [1], is a monogenic inherited X-linked disease caused by mutations in the alpha galactosidase (GLA) gene, which encodes for the lysosomal enzyme alpha-galactosidase A (α-GalA, EC 3.2.1.22).