ELF3 and Fabry disease: We showed that in addition to an antioxidant effect exerted by ERT itself, the antioxidant treatment with green tea supplementation on top of ERT was able to decrease levels of p22phox, MDA and MYPT-1 phosphorylation, a marker of ROCK activity, while increasing the endogenous antioxidant defences in terms of HO-1 expression [104], suggesting that the distinctive oxidative imbalance of Fabry patients should be taken into consideration in the management and treatment of FD.