SGLT2 inhibitors are known to be effective in preventing kidney function decline with an effect of approximately 0.9 ml per minute per 1.73 m2 (95% CI, 0.61 to 1.25) per year in saved renal function compared to placebo in adults with or without T2D who had an estimated glomerular filtration rate (GFR) of 25 to 75 ml per minute per 1.73 m2 of body surface area [33]. Here, SLC5A2 is linked to type 2 diabetes mellitus.