The PD-1 and PD-L1 gene expression was evaluated in the different subgroups of the CRSwNP patients, including subjects with chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis with nasal polyp and allergy and chronic rhinosinusitis with nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD). Here, CD274 is linked to chronic rhinosinusitis with nasal polyps.