In patients with CHB and CHC, the number of circulating IL-10+ Breg and Tfr cells was positively correlated with serum ALT and AST levels, and the number of circulating IL-10+ Breg cells and Tfr/Tfh ratio in patients with HBeAg+ CHB was markedly higher than those in patients with HBeAg- CHB [106]. This evidence concerns the gene TFRC and cryohydrocytosis.