Immune checkpoint inhibitors (ICI), by targeting the cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) or the Programmed Death receptor 1 (anti-PD-1) or its ligand (anti-PD-L1), can cause immune-related adverse events (irAEs) that may affect all organs, in line with their mechanism of action, i.e., restoring immune response against tumor cells. The gene discussed is CD274; the disease is neoplasm.