CFH and hyperthyroidism: [25] Gopinath et al., in multivariate regression analysis adjusted for age, sex, current smoking, fish consumption, and presence of high risk CFH and ARMS2 variants, demonstrated that overt hyperthyroidism (low TSH and high free T4 levels) in older patients is independently associated with a 3-fold increase in the risk of AMD development; however, they did not verify any significant positive association between serum free T4 levels and incident AMD in their study.