Thus, the abnormal splicing of the chloride channel (CLCN1) is associated with myotonia, that of the insulin receptor (INSR) with insulin resistance, that of the calcium channel (Cav1.1) with muscle weakness, and that of the sodium channel (SCN5A) with arrhythmias [6,7,8,9,10]. Here, INSR is linked to Arrhythmia.