It has been reported that metabolic syndromes [31], severe coronary artery diseases [32], and atherosclerosis in rabbits [33] are associated with decreased serum IL-17A levels as well as decreased HDL-C levels, and the improvement of atherosclerosis in a rabbit model leads to an increase in both levels [33], indicating a positive correlation between HDL-C and IL-17A in cardiometabolic diseases. This evidence concerns the gene IL17A and metabolic syndrome.