In contrast, HDL is enriched in anti-inflammatory lipids, and interaction of HDL with immune cells induces cholesterol efflux from cell membranes, suppresses immune cell activation, acts on dendritic cells, suppresses their expression of CD40, 80, 86, or class II molecules, and reduces their ability to differentiate naïve T cells into Th1 or Th17 cells, indicating the protective effects of HDL from psoriasis [15]. The gene discussed is CD40; the disease is psoriasis.