BACE1 and Alzheimer disease: The levels of β-site amyloid precursor protein-cleaving enzyme-1(BACE-1), γ-secretase, soluble Aβ42, soluble sAPPβ and sAPPα, p-Tau-181, and p-Tau-S396 were dramatically higher (3- to 20-fold) in ADEs than in NDEs in both AD patients and matched normal subjects, which suggests that ADE cargo proteins may facilitate an investigation of the mechanisms of cellular interactions and biomarkers in AD [88].