COL18A1 and neoplasm: In order to reduce the defects of endostatin, we mutated the RGIRGAD sequence at the 25–31 position of human endostatin into the RGDRGD sequence in our previous works so that endostatin could bind to integrin αvβ3 on the tumor cell membrane via the RGD sequence, and we obtained mutated endostatin with stronger anti-tumor activity [12].