It was also revealed that more than 3 months of supplementation with fish oils containing omega-3 PUFA resulted in alkaline phosphatase (ALP), liver fibrosis, alanine aminotransferase (ALT), triglyceride (TG) and fibroblast growth factor 21 (FGF21) reductions and adiponectin increase [40]. This evidence concerns the gene FGF21 and Hepatic fibrosis.