CD274 and neoplasm: Preexisting interstitial pneumonia was not considered as an exclusion criterion even for a 72-year-old patient affected by pleomorphic carcinoma (PD-L1 TPS 65%) treated with Pembroluzumab as second-line treatment obtaining a remarkable tumor shrinkage and a prolonged response even after two years after treatment discontinuation; Pembrolizumab was permanently stopped due to hands arthralgia after ten months and the patients did not experienced any exacerbation of interstitial pneumonia [125].