In contrast, the inhibitory effect of an anti-CXCR2 monoclonal antibody on IL-8-induced proliferation of BPH cells was weak but not statistically significant, indicating that the autocrine/paracrine proliferation of IL-8 was mainly mediated by binding to the IL-8 receptor CXCR1 [58]. This evidence concerns the gene CXCL8 and benign prostatic hyperplasia.