Neri et al. report on more key pH regulators in cancer cells including isoforms of the carbonic anhydrases 2, 9, and 12 (CA2, CA9, CA12), the Na+/H+ exchanger 1 (NHE1) and the plasma membrane proton pump vacuolar ATPase (V-ATPase) [2,4]. The gene discussed is CA2; the disease is cancer.