The RNA-sequencing of urinary vesicles (extracellular) on molecular modification in the mineralocorticoid receptor activation showed changes in the mRNA found in urine supernatant. This may contribute to better-tailored pharmacological treatment in mineralocorticoid signaling disorders such as resistant hypertension. Furthermore, it may help in the noninvasive identification of new putative biomarkers for cardiovascular and renal diseases and also predict drug responses. Here, NR3C2 is linked to Hypertension resistant to conventional therapy.