LBP and type 1 diabetes mellitus: We showed that T1D individuals with DR exhibit a loss of intestinal barrier function that is identified with multiple biomarkers of gut barrier disruption, such as peptidoglycan (PGN), lipopolysaccharide-binding protein (LBP), and fatty-acid-binding protein 2 (FABP2); this increase in gut permeability was associated with gut-derived immune cell activation and, importantly, with worsening DR severity.