Given the common involvement of TLR4 signaling and NLRP3 inflammasomes in both hypercholesterolemia and the pathogenesis of AP, recent studies indicated that both high total cholesterol (TC, >240 mg/dL) and high low-density lipoprotein cholesterol (LDL-C, >150 mg/dL) levels within 24 h of admission are independently associated with an increased risk of SAP [13,14]. Here, NLRP3 is linked to alkaline phosphatase measurement.