NOS3 and alpha 1-antitrypsin deficiency: DeMeo et al. [21] explored GSTP1 and NOS3 polymorphisms in a family-based study and were unable to confirm the association between the GSTP1 105Val polymorphism and COPD in AATD, proposed by Rodriguez et al. [14], or the increased frequencies of the NOS3 774T and 894T alleles in AATD individuals with severe lung disease, suggested by Novoradovsky et al. [11].