The GSTP1 105Val frequency was significantly increased in the AATD group (vs. healthy controls: odds ratio [OR] 2.09, 95% confidence interval [CI] 1.17–3.72; vs. COPD group: OR 2.41, 95% CI 1.27–4.59) but was comparable between COPD patients and healthy controls. This evidence concerns the gene GSTP1 and chronic obstructive pulmonary disease.