HIF3A and gestational diabetes: Similarly, miR-29b was found to be downregulated in the placenta of GDM patients and to target hypoxia-inducible factor 3A (HIF3A), which has two specific binding sites for miR-29b in the 3’-UTR, resulting in increased HIF3A expression, promoting trophoblast cell migration, and participating in GDM development [143].