Another study found that circMAP3K4 was highly expressed in the placenta of GDM patients, and additionally, circMAP3K4 could inhibit the insulin-PI3K/Akt signaling pathway via the miR-6795-5p/PTPN1 axis, which may be associated with GDM-associated insulin resistance [149]. Here, PTPN1 is linked to gestational diabetes.