In our studies in the GBM mouse model, we have observed that repolarization of the TAMs from M2 to the M1 state is associated with a dramatic increase in the expression of CCL2 (a.k.a MCP-1) in the microglia/macrophages, which is concomitant with the recruitment of activated NK cells into the TME [15]. This evidence concerns the gene CCL2 and glioblastoma.