We have shown in a series of publications that curcumin (CC) and synergistic formulations of CC and other polyphenols, such as resveratrol (Res) and epicatechin gallate (ECG) (TriCurin), can inhibit STAT-3 in the microglia and macrophages in GBM as well as HPV+ cervical cancer, thereby repolarizing these cells in the TME to the M1 phenotype [15,19,20,23]. Here, STAT3 is linked to glioblastoma.