The latter encompasses the prior entity of AML with mutated RUNX1, expanded to include the other eight genes shown to be related to AML arising from MDS or MDS/MPN as follows: ASXL1; BCOR; EZH2; SF3B1; SRSF2; STAG2; U2AF1; and ZRSR2. Here, ASXL1 is linked to acute myeloid leukemia.