HSP90 also plays a crucial role in the regulation of the activity of signaling pathways that are associated with cancer, such as the protein kinase B (Akt)/mammalian target of the rapamycin (mTOR) pathway, and the rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase (MAPK) pathway [21]. Here, WNK2 is linked to fibrosarcoma.