TGFBI and cerebral creatine deficiency syndrome: TGFBI, as a gene with a high degree of pleiotropy, causes various types of CDs, including epithelial basement membrane dystrophy (EBMD), Reis–Bucklers corneal dystrophy (RBCD), Thiel–Behnke corneal dystrophy (TBCD), LCD, granular corneal dystrophy type 1 (GCD1), and granular corneal dystrophy type 2 (GCD2).