CXCL8 and cystic fibrosis: For instance, earlier studies demonstrated that the short-term (6–11day old) primary cultures of F508del/F508del CF human bronchial epithelia (HBE) exhibit a hyperinflammatory phenotype characterized by increases in the baseline and bradykinin-stimulated IL-8 secretion when compared to short-term primary cultures of normal HBE [224].