CFTR and cystic fibrosis: The epoxide hydrolase termed CFTR Inhibitory Factor (Cif), secreted by P. aeruginosa and delivered by the bacterial outer membrane vesicles to the bronchial epithelial cells [70,71,72,73], acquires a prominent role in CF because of its effect on the degradation of the CFTR protein, achieved by increasing its ubiquitination and proteasomal degradation [74].