The following core statements could be derived from the results which suggests that resveratrol enhances, at least in part through the use of β1-integrin receptors, (I) intensifies the effectiveness of 5-FU in CRC cells, (II) paves the way for 5-FU efficacy in therapy-resistant CRC cells, (III) triggers the epithelial phenotype, (IV) targets the vascularisation marker HIF-1α and (V) specifically inhibits the association of β1-integrin with HIF-1α in 5-FU-resistant and non-resistant CRC cells. Here, HIF1A is linked to colorectal carcinoma.