HIF1A and colorectal carcinoma: For this purpose, resveratrol not only acts as pro-apoptotic (caspase-3) but also induces its effect against inflammation (NF-kB), vascularisation (VEGF), and cancer stem cells (CD44, CD133, ALDH1), and also targets the β1-integrin/HIF-1α axis that is highly pronounced in CRC cells.