Moreover, HIF-1α has already been suggested as a potential target for resveratrol in various tumor types such as prostate and pancreatic cancers [51,52] or colon carcinoma [35,36], but to the best of our knowledge, the present work is the first study to demonstrate the potential of resveratrol to target HIF-1α in inducing cancer cell chemosensitisation in CRC. Here, HIF1A is linked to familial pancreatic carcinoma.