While there is initial evidence of resveratrol-binding HIF-1α restriction in HT-29 [35] and LoVo [36] colon carcinoma cells, thus exploring of the effects of resveratrol on HIF-1α signaling in HCT-116 and 5-FU-resistant HCT-116R CRC cells offers particular scientific interest. The gene discussed is HIF1A; the disease is colorectal carcinoma.