HIF1A and cancer: In summary, resveratrol reduces inflammation, vascularisation, particularly by inhibiting HIF-1α, and suppresses cancer stem cell formation and increases apoptosis in both HCT-116 and HCT-116R cells, acting chemosensitising and synergistic agent in combination with chemotherapeutic drug, 5-FU at least proportionally via β1-integrin receptors.