HIF1A and colorectal carcinoma: And now, through this study, we have identified the effect of resveratrol through the β1-integrin signaling pathway as the fulcrum of numerous anti-CRC mechanisms such as proliferation and invasion, and appropriately, showed the importance of β1-integrin receptors in angiogenesis via targeting HIF-1α, and also in chemosensitisation to 5-FU.