CRABP1 is a highly conserved cytosolic protein and is expressed in multiple cell types, including embryonic stem cells (ESCs) [5], cardiomyocytes [7], adipocytes [8,9], and motor neurons (MNs) [10], etc. In ESC, CRABP1-RA modulates cell cycle progression, and deleting CRABP1 from ESC accelerates cell cycle progression [5], supporting the notion that CRABP1 can be a tumor suppressor [11,12]. This evidence concerns the gene CRABP1 and neoplasm.