One example is the lncRNA SET and MYND domain containing 3 (SMYD3), which is significantly induced by HBx and is related to an extracellular signal-regulated kinase (ERK) and protein kinase B/ glycogen synthase kinase 3 beta (AKT/GSK3-β) signaling activation, resulting in aberrant cell proliferation and metastasis with poor HCC prognosis [157]. The gene discussed is SMYD3; the disease is hepatocellular carcinoma.