DNMT1 and hepatocellular carcinoma: In addition, HBx drives DNMT1 and DMNT3A towards the promoter region of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein family 2 (ASPP2) and leads to their downregulation with further effects for the p53-dependent apoptosis and HCC progression [137].